反应详情

In a 3 L two-neck round bottom flask, equipped with a reflux condenser and a dropping funnel, 2 L of hydrochloric acid (d=1.16) were stirred and heated to boiling. A solution of 6.06 g (30.3 mmol) of 1-(6-methoxy-2-naphthyl)-1-ethanone (prepared as described in Arsenijevic et al., Org. Synth. Coll. 6:34 (1988), the disclosure of which is incorporated herein by reference) in a minimum amount of dichloromethane was added, and the mixture was stirred and heated at reflux for 2 hours. The hot solution was filtered through a mineral wool plug to remove oily residue. The solid that separated after cooling was filtered on a glass frit and dissolved in 130 mL of ethyl acetate. The solution was washed with brine, dried with anhydrous magnesium sulfate and evaporated to give 5 g (89%) of 1-(6-hydroxy-2-naphthyl)1-ethanone.

1. customIn a 3 L two-neck round bottom flask, equipped with a reflux condenser and a dropping funnel
2. temperatureheated to boiling
3. additionwas added
4. temperatureheated
5. temperatureat reflux for 2 hours
6. filtrationThe hot solution was filtered through a mineral wool plug
7. customto remove oily residue
8. customThe solid that separated
9. temperatureafter cooling
10. filtrationwas filtered on a glass frit
11. dissolutiondissolved in 130 mL of ethyl acetate
12. washThe solution was washed with brine
13. dry with materialdried with anhydrous magnesium sulfate
14. customevaporated