反应详情

To a stirring suspension of 1-Boc-4-(6-chloro-naphthalen-2-ylsulfonyl)piperazine (2.8g, 6.8 mmol) in dioxane (50 mL) was added 4 M HCl in dioxane (5 mL, 40 mmol). After stirring overnight at room temperature, the solvent was evaporated in vacuo, and the residue was dissolved in water. The aqueous phase was and made basic with 5 N NaOH and extracted twice with ethyl acetate. The combined extracts were washed with water and brine, then dried over sodium sulfate and evaporated to 2.1 g (100%) solid.

1. customthe solvent was evaporated in vacuo
2. dissolutionthe residue was dissolved in water
3. extractionextracted twice with ethyl acetate
4. washThe combined extracts were washed with water and brine
5. dry with materialdried over sodium sulfate
6. customevaporated to 2.1 g (100%) solid