HuagongsheHuagongshe Chemistry Print Report · For research reference only
benzyl (2R, 4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidine-1-carboxylate → (2R, 4R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | benzyl (2R, 4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidine-1-carboxylate | HCID 86759290 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2R, 4R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-4-ol | HCID 11460944 | 97.3% |
Reaction Steps
To a solution of benzyl (2R, 4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidine-1-carboxylate (350 mg) in MeOH (15 mL) was added 10%Pd-C (wet) (50 mg), and the mixture was stirred under hydrogen atmosphere at room temperature for 1 hour. The catalyst was removed by filtration and the filtrate was evaporated to give (2R, 4R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-4-ol (236.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06660759B1 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-0e86f3adec6f48368348bea596168505 |
| Source note | uspto-grants-2003_12 |