Lithium hydroxide, monohydrate → 3-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid

HRID 432075노트

반응식

HRID 432075 반응식
O.[OH-].[Li+].C([O:6][C:7](=[O:27])[CH:8]([O:24][CH2:25][CH3:26])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)C>O.O1CCOCC1>[CH2:17]([O:16][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][CH:8]([O:24][CH2:25][CH3:26])[C:7]([OH:27])=[O:6])=[CH:15][CH:14]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 110779683-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester

생성물 1

HCID 109245703-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid수율 99.2%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매2회

실험 절차

Lithium hydroxide hydrate (7.4 g; 177 mmole) dissolved in water (150 ml) was added to a solution of 3-(4-benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester (23.25 g; 70.8 mmole) in dioxan (150 ml). After stirring at room temperature over night dioxan was evaporated in vacuo, water was added and the mixture was washed with diethyl ether. The water phase was acidified with hydrochloric acid (1 M) and extracted with ethyl acetate. The organic phase was washed with water and brine, dried and the solvent was evaporated in vacuo to give 21.1 g (yield 99.2%) of 3-(4-benzyloxyphenyl)-2-ethoxypropanoic acid.

후처리

  1. customwas evaporated in vacuo, water
  2. additionwas added
  3. washthe mixture was washed with diethyl ether
  4. extractionextracted with ethyl acetate
  5. washThe organic phase was washed with water and brine
  6. customdried
  7. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-badedda8f86446488cfa98043a76f498
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660879B2

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