HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester → Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester | HCID 11099514 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate | HCID 9816147 | 76% |
Reaktionsschritte
3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester was hydrogenated at atmospheric pressure for 2 hours in ethyl acetate using Pd/C as catalyst. Purification by chromatography on silica gel using toluen:ethyl acetate as eluant gave 3.83 g (yield in 3 steps 76%) of (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid ethyl ester.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06660879B2 |
| Quelldatensatz | uspto-grants-2003_12 |
| ORD ID | ord-ca88f86003e6446093eab14191cfa5ce |
| Quellennotiz | uspto-grants-2003_12 |