反应详情

A suspension of 3,4-dihydro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidin-4-one (2.4 g) in phosphorus oxychloride (20 ml) was refluxed for 2 hours, and evaporated. To the residue were added aqueous sodium bicarbonate solution and chloroform, and stirred at ambient temperature for 2 hours. The organic layer was obtained and washed with water. After evaporated, the residue was dissolved in ethyl acetate-diisopropyl ether mixture (1:6 v/v). The precipitates were filtered off, and the filtrate was evaporated to give 4-chloro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (2.09 g).

1. temperaturewas refluxed for 2 hours
2. customevaporated
3. additionTo the residue were added aqueous sodium bicarbonate solution and chloroform
4. customThe organic layer was obtained
5. washwashed with water
6. customAfter evaporated
7. dissolutionthe residue was dissolved in ethyl acetate-diisopropyl ether mixture (1:6 v/v)
8. filtrationThe precipitates were filtered off
9. customthe filtrate was evaporated