反应详情

To 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)-2-(1H)pyrimidone (5.0 g) was added phosphorus oxychloride (50 ml). The mixture was refluxed for 7 hours and evaporated under reduced pressure. The resulting syrup was triturated in a mixture of ice and water, neutralized with aqueous sodium bicarbonate and extracted with chloroform. The extract was dried and evaporated under reduced pressure. The residue was chromatographed on silica gel using chloroform to give 2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (3.26 g).

1. temperatureThe mixture was refluxed for 7 hours
2. customevaporated under reduced pressure
3. customThe resulting syrup was triturated in a mixture of ice and water
4. extractionextracted with chloroform
5. customThe extract was dried
6. customevaporated under reduced pressure
7. customThe residue was chromatographed on silica gel