反应详情

A solution of tin (II) chloride dihydrate (9.50 g) and 4-(4-bromophenyl)-8-nitroquinoline (4.60 g) in 50 mL absolute ethanol was refluxed for 6 hours. The reaction mixture was cooled to room temperature and then made alkaline with 30% KOH solution. The precipitated solid was filtered off, and dissolved in chloroform. The filtrate was extracted with ether. The ether extract and chloroform solution were combined and dried over MgSO4. Evaporation gave a solid with 1H-NMR spectral signals consistent with 8-amino-4-(4-bromophenyl)quinoline.

1. filtrationThe precipitated solid was filtered off
2. dissolutiondissolved in chloroform
3. extractionThe filtrate was extracted with ether
4. extractionThe ether extract
5. dry with materialdried over MgSO4
6. customEvaporation