Potassium Carbonate → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

HRID 432568Notes

Reaction equation

HRID 432568 reaction equation
C([O:4][CH2:5][C:6]([CH3:20])([CH3:19])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH3:19][C:6]([CH3:20])([CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)[CH2:5][OH:4]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 545188152,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

Product 1

HCID 187597722,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate (20 mg) in methanol was added saturated solution of K2CO3 in metanol (1.5 mL) and the resulting solution was stirred at room temperature for 1 hour. MeOH was evaporated in vacuo and water was added followed by CH2Cl2. The aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dired over Na2SO4 and evaporated in vacuo to afford the title compound as a slightly yellow oil.

Workup

  1. customMeOH was evaporated in vacuo and water
  2. additionwas added
  3. extractionThe aqueous layer was extracted with CHCl3
  4. washthe combined organic layers were washed with brine
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-3abaf1aa7a594129a08f557797f95ef6
Source dataset
uspto-grants-2003_12
Patent number
US06664238B1

Reaction notes

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