Dimethylamine, hydrochloride → HCID 6918573, compound

HRID 432589Notes

Reaction equation

[C:1]([CH2:4][NH:5][C:6]([NH:8][CH2:9][C:10]1[CH:28]=[CH:27][C:13]([C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[CH:12][C:11]=1[CH3:29])=[O:7])([OH:3])=O.Cl.[CH3:31][NH:32][CH3:33]>>[CH3:31][N:32]([CH3:33])[C:1](=[O:3])[CH2:4][NH:5][C:6]([NH:8][CH2:9][C:10]1[CH:28]=[CH:27][C:13]([C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[CH:12][C:11]=1[CH3:29])=[O:7]

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 15896092HCID 15896092, compound

Product 1

HCID 6918573HCID 6918573, compound

Procedure

The carboxylic acid from Example 6 (0.07 g, 0.18 mmol) was reacted with dimethylamine hydrochloride (0.072 g, 0.88 mmol) according to the procedure in Example 7. The product was purified by flash chromatography on silica (eluant chloroform:methanol:acetic acid 98:1:1) to give a white solid; yield 0.08 g (11%).

Workup

customThe product was purified by flash chromatography on silica (eluant chloroform:methanol:acetic acid 98:1:1)
customto give a white solid

Sources & evidence

ORD record: ord-da26298982e44223976ad4ebfc219989
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06664249B1

Reaction notes

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