tert-Butyl carbamate → HCID 18759809, compound

HRID 432592Notes

Reaction equation

HRID 432592 reaction equation
C(N)(OC(C)(C)C)=O.Cl.C(OC([NH:17][CH2:18][C:19]1[CH:36]=[CH:35][C:22]([C:23]([N:25]2[CH2:31][CH2:30][CH2:29][CH2:28][C:27]3[S:32][CH:33]=[CH:34][C:26]2=3)=[O:24])=[CH:21][C:20]=1[Cl:37])=O)(C)(C)C>Cl.O1CCOCC1>[ClH:37].[NH2:17][CH2:18][C:19]1[CH:36]=[CH:35][C:22]([C:23]([N:25]2[CH2:31][CH2:30][CH2:29][CH2:28][C:27]3[S:32][CH:33]=[CH:34][C:26]2=3)=[O:24])=[CH:21][C:20]=1[Cl:37]

Participants

4

Reactant 2

HCID 77922tert-Butyl carbamateHCID 18759813HCID 18759813, compound

Product 1

HCID 18759809HCID 18759809, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

The BOC amine from 11A was dissolved in 4N HCl/dioxan (30 ml). The mixture was stirred at room temperature for 40 min then concentrated in vacuo to leave a tan solid; yield 0.41 g (63%, for 2 steps).

Workup

  1. concentrationthen concentrated in vacuo
  2. customto leave a tan solid

Sources & evidence

ORD record
ord-c4b43dda80cd42598c4df9b9708dded5
Source dataset
uspto-grants-2003_12
Patent number
US06664249B1

Reaction notes

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