2-Hydroxybenzonitrile → HCID 10112167, compound

HRID 432635Notes

Reaction equation

HRID 432635 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[OH:32])#[N:25]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[C:24]#[N:25])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 119072-HydroxybenzonitrileHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Product 1

HCID 10112167HCID 10112167, compound

Procedure

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (110 mg, 0.337 mmol) and 2-cyanophenol were reacted as starting materials at 150° C. for 24 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow amorphous solid (121.4 mg, 88.1%). Melting point: 197.7-201.1° C. (ethyl acetate-hexane).

Workup

  1. customat 150° C.
  2. customfor 24 hours

Sources & evidence

ORD record
ord-66998b500da54cbb9459def23921940e
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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