3-Cyanophenol → HCID 10294943, compound

HRID 432636Notes

Reaction equation

HRID 432636 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[C:24]([C:26]1[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=1)#[N:25]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:28]3[CH:29]=[CH:30][CH:31]=[C:26]([C:24]#[N:25])[CH:27]=3)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 133943-CyanophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Product 1

HCID 10294943HCID 10294943, compound

Procedure

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (175 mg, 0.536 mmol) and 3-cyanophenol were reacted as starting materials at 150° C. for 19 hours and post-treatment was then conducted, whereby the title compound was obtained as colorless prisms (165 mg, 75.2%). Melting point: 169.9-172.7° C. (ethyl acetate-diethyl ether-hexane).

Workup

  1. customat 150° C.
  2. customfor 19 hours

Sources & evidence

ORD record
ord-9587c15cf2484bc8af48bb2e69156d84
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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