3,4-Bis(4-methoxyphenyl)-6-chloropyridazine → HCID 18760033, compound

HRID 432638Notes

Reaction equation

HRID 432638 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[OH:24][C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:24][C:25]3[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=3)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazineHCID 178418642HCID 178418642, compound

Product 1

HCID 18760033HCID 18760033, compound

Procedure

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (200 mg, 0.613 mmol) and 4-hydroxypyridine were reacted as starting materials at 150° C. for 22 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow crystalline powder (201.6 mg, 85.2%). Melting point: 186.8-188.8° C. (hexane).

Workup

  1. customat 150° C.
  2. customfor 22 hours

Sources & evidence

ORD record
ord-504710ad68b34f1c865cb401fbdaa054
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

Loading…