2,4-Difluorophenol → HCID 10222036, compound

HRID 432639Notes

Reaction equation

HRID 432639 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:3]=1.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[OH:30]>>[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[O:30][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1230512,4-DifluorophenolHCID 18760010HCID 18760010, compound

Product 1

HCID 10222036HCID 10222036, compound

Procedure

In a similar manner as in Example 2, 6-chloro-3-(4-methoxyphenyl)-4-(4-pyridyl)pyridazine (150 mg, 0.504 mmol) and 2,4-difluorophenol were reacted as starting materials at 150° C. for 25 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow amorphous solid (157.0 mg, 79.6%).

Workup

  1. customat 150° C.
  2. customfor 25 hours

Sources & evidence

ORD record
ord-ac96336e440b4aeebf1c9589554594f3
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

Loading…