Phosphorus oxychloride → HCID 18760041, compound

HRID 432640Notes

Reaction equation

HRID 432640 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][C:12](=O)[NH:13][N:14]=2)=[CH:5][CH:4]=1.P(Cl)(Cl)([Cl:24])=O>C1C=CC=CC=1>[Cl:24][C:12]1[N:13]=[N:14][C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[C:10]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 18759983HCID 18759983, compound

Product 1

HCID 18760041HCID 18760041, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

6-(4-Methoxyphenyl)-5-phenyl-2H-pyridazin-3-one [WO 9925697] (2.76 g, 9.60 mmol) and phosphorus oxychloride (2.8 mP) were stirred at 90° C. for 5 hours in benzene. The reaction mixture was processed in a similar manner as in Example 22, whereby the title compound was obtained as a pale yellow-brown oil (1.83 g, 64.3%)

Sources & evidence

ORD record
ord-823c66e84a4c4cada3fbc891922153a3
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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