2,4-Difluorophenol → HCID 18760000, compound

HRID 432644Notes

Reaction equation

HRID 432644 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH:3]=1.[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[OH:31]>>[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[O:31][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1230512,4-DifluorophenolHCID 18760022HCID 18760022, compound

Product 1

HCID 18760000HCID 18760000, compound

Procedure

In a similar manner as in Example 2, 6-chloro-4-(4-fluorophenyl)-3-[4-(methylthio)phenyl]pyridazine (198 mg, 0.599 mmol) and 2,4-difluorophenol were reacted as starting materials at 150° C. for 20 hours and post-treatment was then conducted, whereby the title compound was obtained as pale yellow crystals (197 mg, 77.4%). Melting point: 140.6-143.4° C. (acetone-water).

Workup

  1. customat 150° C.
  2. customfor 20 hours

Sources & evidence

ORD record
ord-b135193b91394bd58099b00c137bb560
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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