Thiophenol → HCID 10185122, compound

HRID 432646Notes

Reaction equation

HRID 432646 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][C:19](Cl)=[CH:18][CH:17]=2)[CH:3]=1.[C:23]1([SH:29])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:15][S:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[N:6]=[N:7][C:2]([S:14][C:11]3[CH:12]=[CH:13][CH:8]=[CH:9][CH:10]=3)=[CH:3][C:4]=2[C:16]2[CH:21]=[CH:20][C:19]([S:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:18][CH:17]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 7969ThiophenolHCID 18760020HCID 18760020, compound

Product 1

HCID 10185122HCID 10185122, compound

Procedure

In a similar manner as in Example 2, 6-chloro-4-(4-chlorophenyl)-3-[4-(methylthio)phenyl]pyridazine (150 mg, 0.303 mmol) and thiophenol (119 mg) were reacted as starting materials at 150° C. for 20 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow crystalline powder (85.0 mg, 39.8%). Melting point: 53.3-56.2° C.(diethyl ether-hexane).

Workup

  1. customat 150° C.
  2. customfor 20 hours

Sources & evidence

ORD record
ord-fba8f2adb9e24c8da0b8bfa379f55994
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

Loading…