2,4-Difluorophenol → HCID 10297058, compound

HRID 432647Notes

Reaction equation

HRID 432647 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH:3]=1.[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[OH:31]>ClCCl.CCCCCC>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([C:4]2[CH:3]=[C:2]([O:31][C:25]3[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=3[F:23])[N:7]=[N:6][C:5]=2[C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 1230512,4-DifluorophenolHCID 18760020HCID 18760020, compound

Product 1

HCID 10297058HCID 10297058, compound

Reagents, catalysts & solvents 1

HCID 21226440Methylenechloride HexaneSolvent

Procedure

In a similar manner as in Example 2, 6-chloro-4-(4-chlorophenyl)-3-[4-(methylthio)phenyl]pyridazine (230.0 mg, 0.662 mmol) and 2,4-difluorophenol were reacted as starting materials at 150° C. for 20 hours and post-treatment was then conducted, whereby the title compound was obtained as colorless plates (dichloromethane-hexane, 216.2 mg, 74.0%). Melting point: 163.2-164.0° C.

Workup

  1. customat 150° C.
  2. customfor 20 hours

Sources & evidence

ORD record
ord-84f2adfd236f4e7682dc212d947aea6f
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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