2,4-Difluorophenol → HCID 18760030, compound

HRID 432648Notes

Reaction equation

HRID 432648 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=2)=[C:4]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH:3]=1.[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[OH:34]>>[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[O:34][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=2)=[C:4]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 1230512,4-DifluorophenolHCID 18760019HCID 18760019, compound

Product 1

HCID 18760030HCID 18760030, compound

Procedure

In a similar manner as in Example 2, 6-chloro-3-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)pyridazine (203 mg, 0.589 mmol) and 2,4-difluorophenol were reacted as starting materials at 150° C. for 20 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow amorphous solid (260 mg, quantitative).

Workup

  1. customat 150° C.
  2. customfor 20 hours

Sources & evidence

ORD record
ord-7293b89d1a094a0f8c1639b9f679847c
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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