3,4-Bis(4-methoxyphenyl)-6-chloropyridazine → HCID 18759995, compound

HRID 432654Notes

Reaction equation

HRID 432654 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH2:24]([NH:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=1[F:35])[CH2:25][CH3:26]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([N:27]([CH2:24][CH2:25][CH3:26])[C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=3[F:35])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazineHCID 18760017HCID 18760017, compound

Product 1

HCID 18759995HCID 18759995, compound

Conditions

Temperature
100 °C

Procedure

In a similar manner as in Example 2, 3,4-bis-(4-methoxyphenyl)-6-chloropyridazine (180 mg, 0.551 mmol) and N-(n-propyl)-2,4-difluoroaniline, as starting materials, were stirred 100° C. for 12 hours and then reacted at 170° C. for 10 hours, and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow-brown amorphous solid (137.5 mg, 54.1%).

Workup

  1. customreacted at 170° C. for 10 hours

Sources & evidence

ORD record
ord-b8941993ba774d07be7d869f227eb5bb
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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