3,4,5-Trimethoxyaniline → HCID 18759993, compound

HRID 432655Notes

Reaction equation

HRID 432655 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34])[NH2:29]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([NH:29][C:28]3[CH:30]=[C:31]([O:35][CH3:36])[C:32]([O:33][CH3:34])=[C:26]([O:25][CH3:24])[CH:27]=3)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 322853,4,5-TrimethoxyanilineHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Product 1

HCID 18759993HCID 18759993, compound

Procedure

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (150.0 mg, 0.459 mmol) and 3,4,5-trimethoxy aniline were reacted as starting materials at 140° C. for 5 hours and post treatment was then conducted, whereby the title compound was obtained as a pale yellow crystalline powder (155.0 mg, 71.3%). Melting point: 125.4-126.3° C. (chloroform-hexane).

Workup

  1. customat 140° C.
  2. customfor 5 hours

Sources & evidence

ORD record
ord-b29f734cfa0747a1b8d642fa2711d452
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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