Morpholine → HCID 18760016, compound

HRID 432656Notes

Reaction equation

HRID 432656 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Product 1

HCID 18760016HCID 18760016, compound

Procedure

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (125.5 mg, 0.384 mmol) and morpholine were reacted as starting materials at 100° C. for 15 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow crystalline powder (115.2 mg, 79.5%). Melting point: 188.0-190.3° C. (chloroform-diethylether).

Workup

  1. customat 100° C.
  2. customfor 15 hours

Sources & evidence

ORD record
ord-4c88ad9567b345a387933365c82498ce
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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