HCID 18760173, compound → HCID 18760188, compound

HRID 432693Notes

Reaction equation

HRID 432693 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[C:7][CH2:8][O:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[CH:16][C:15]=2[N:14]=[CH:13]1>[Pd].CO>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[CH:16][C:15]=2[N:14]=[CH:13]1

Participants

4

Reactant 1

HCID 18760173HCID 18760173, compound

Product 1

HCID 18760188HCID 18760188, compoundYield 94.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Using the general method of Example 3 Part B, 1-{2-[(3-thien-2-ylprop-2-ynyl)oxy]ethyl}-1H-imidazo[4,5-c]quinoline (9.5 g, 28.49 mmol) was reduced with palladium on carbon (10%, 1 g) in methanol (25 mL) to provide 9.1 g of 1-[2-(3-thien-2-ylpropoxy)ethyl]-1H-imidazo[4,5-c]quinoline as a brown oil.

Sources & evidence

ORD record
ord-9d8776f1e7a440cbb52218b0704803f3
Source dataset
uspto-grants-2003_12
Patent number
US06664260B2

Reaction notes

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