Triphenylphosphine → HCID 10294704, compound

HRID 432707Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][C:5]1[N:6]([CH2:21][CH2:22][O:23][CH2:24][CH2:25][CH2:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)[C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]3N=N[N:19]=[C:9]3[C:8]=2[N:20]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[CH3:1][O:2][CH2:3][CH2:4][C:5]1[N:6]([CH2:21][CH2:22][O:23][CH2:24][CH2:25][CH2:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)[C:7]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[C:9]([NH2:19])[C:8]=2[N:20]=1

Participants

Reactant 2

HCID 11776Triphenylphosphine

HCID 18760205HCID 18760205, compound

Product 1

HCID 10294704HCID 10294704, compoundYield 27.7%

Procedure

5-(2-methoxyethyl)-6-[2-(3-pyridin-3-ylpropoxy)ethyl]-6H-imidazo[4,5-c]tetraazolo[1,5-a]quinoline (0.35 g, 0.80 mmol) was treated with triphenylphosphine (0.28 g, 1.20 mmol) using the general procedure described in Part B of example 35. The crude product was crystallized from ether to yield 90 mg of 2-(2-methoxyethyl)-1-[2-(3-pyridin-3-ylpropoxy)ethyl]-1H-imidazo[4,5-c]quinolin-4-amine as off-white crystals.

Workup

customThe crude product was crystallized from ether

Sources & evidence

ORD record: ord-fb7929c38d23473e9a8b13a2ed8e25f3
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06664260B2

Reaction notes

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