反应详情

The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with ethyl nipecotate (209.9 mg; 1.33 mmol and benzyl chloroformate (190 μl; 1.33 mmol). The crude product was distilled at 220° C./0.1 torr, giving ethyl 1-benzyloxycarbonyl-3-piperidinecarboxylate (236.5 mg) as a colorless oil. MS m/Z (positive ion) 539 ([dimer-OEt]+; 50), 337 (M+2Na+; 25), 314 (M+Na+; 50), 292 (MH+; 100), 247.5 (M-OEt; 90), 158 (50).

1. distillationThe crude product was distilled at 220° C./0.1 torr