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N,N-Dimethylethylenediamine → 2-Dimethylaminoethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylethylenediamine | HCID 66053 | — |
| 反応物 | Ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate | HCID 12114708 | — |
| 反応物 | 1-(2-(Thiophen-2-yl)acetyl)piperidine-3-carboxylic acid | HCID 16790995 | — |
| 生成物 | 2-Dimethylaminoethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxamide | HCID 18760270 | — |
反応手順
The reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with 1-(2-thiopheneacetyl)-3-piperidine carboxylic acid (572.1 mg; 2.26 mmol) and commercially available N,N-dimethyl ethylenediamine (250 μl; 2.28 mmol). The crude product was purified by chromatography on silica, eluting with 70% methanol in dichloromethane, giving 2-dimethylaminoethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxamide (128.3 mg) as a colorless oil. MS m/z (positive ion) 324 (MH+; 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06664271B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-cdd6d6d699ff4dff8ed9b4e3c017ea97 |
| 出典メモ | uspto-grants-2003_12 |