反应详情

The reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with 1-(2-thiopheneacetyl)-3-piperidine carboxylic acid (572.1 mg; 2.26 mmol) and commercially available N,N-dimethyl ethylenediamine (250 μl; 2.28 mmol). The crude product was purified by chromatography on silica, eluting with 70% methanol in dichloromethane, giving 2-dimethylaminoethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxamide (128.3 mg) as a colorless oil. MS m/z (positive ion) 324 (MH+; 100).

1. customThe crude product was purified by chromatography on silica
2. washeluting with 70% methanol in dichloromethane