Ammonia → (S)-1-(2-Thiopheneacetyl)-3-piperidinecarboxylic Acid Ammonium Salt

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Reaction Steps

A small amount of (S)-1-(2-thiopheneacetyl)-3-piperidine carboxylic acid was dissolved, with warming, in ethyl acetate. An excess amount of ammonia in methanol was added. Diethyl ether was then added to the cloudy mixture and a precipitate formed. The product was isolated by centrifugation and decanting, and was then dried under reduced pressure at ambient temperature. This gave (S)-1-(2-thiopheneacetyl)-3-piperidinecarboxylic acid ammonium salt as a white solid. MS m/z (positive ion) 254 (MH+; 100).

Provenance & Evidence