反应详情

A small amount of (S)-1-(2-thiopheneacetyl)-3-piperidine carboxylic acid was dissolved, with warming, in ethyl acetate. An excess amount of ammonia in methanol was added. Diethyl ether was then added to the cloudy mixture and a precipitate formed. The product was isolated by centrifugation and decanting, and was then dried under reduced pressure at ambient temperature. This gave (S)-1-(2-thiopheneacetyl)-3-piperidinecarboxylic acid ammonium salt as a white solid. MS m/z (positive ion) 254 (MH+; 100).

1. customa precipitate formed
2. customThe product was isolated by centrifugation
3. customdecanting
4. customwas then dried under reduced pressure at ambient temperature