1,2,3,6-Tetrahydropyridine → HCID 9815869, compound

HRID 432871Notes

Reaction equation

HRID 432871 reaction equation
[NH:1]1[CH2:6][CH:5]=[CH:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]=[C:15]=[O:16])=[CH:10][CH:9]=1>O1CCCC1>[F:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([N:1]2[CH2:2][CH:3]=[CH:4][CH2:5][CH2:6]2)=[O:16])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 127501,2,3,6-TetrahydropyridineHCID 709554-Fluorophenyl isocyanate

Product 1

HCID 9815869HCID 9815869, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 1,2,3,6-tetrahydropyridine (82 mg) in tetrahydrofuran (2 ml) was added 4-fluorophenyl-isocyanate (0.112 ml) at ambient temperature. After stirring at ambient temperature for 10 hours, the solvent was removed by evaporation under reduced pressure, and the residue was triturated with diisopropyl ether to give 1-(4-fluorophenylcarbamoyl)-1,2,3,6-tetrahydropyridine (117 mg).

Workup

  1. customthe solvent was removed by evaporation under reduced pressure
  2. customthe residue was triturated with diisopropyl ether

Sources & evidence

ORD record
ord-34905de80b5046e593c37e36acf0048a
Source dataset
uspto-grants-2003_12
Patent number
US06664293B2

Reaction notes

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