Pivaloyl chloride → HCID 18760546, compound

HRID 432889Notes

Reaction equation

HRID 432889 reaction equation
[C:1](Cl)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[CH3:8][C:9]1([CH3:19])[C:14](=[O:15])[O:13][CH2:12][C:11]([CH3:18])([CH2:16][OH:17])[NH:10]1>CN(C)C1C=CN=CC=1.ClCCl>[CH3:8][C:9]1([CH3:19])[C:14](=[O:15])[O:13][CH2:12][C:11]([CH3:18])([CH2:16][O:17][C:1](=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3])[NH:10]1

Participants

5

Reactant 2

HCID 62493Pivaloyl chloride2×HCID 13131206HCID 13131206, compound

Product 1

HCID 18760546HCID 18760546, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 2.63 g (0.021 mol) of pivaloyl chloride is added dropwise to a solution of 3.5 g (0.02 mol) of 3,3,5-trimethyl-5-hydroxymethylmorpholin-2-one (prepared in accordance with J. T. Lai.: Synthesis 122 (1984)) and 0.1 g of 4-dimethylaminopyridine in 20 ml of dichloromethane at 15° C. After stirring for 16 hours, another 0.75 ml of pivaloyl chloride is added and the reaction mixture is stirred for 24 hours.

Workup

  1. stirringthe reaction mixture is stirred for 24 hours

Sources & evidence

ORD record
ord-18d1836fdb644b35854d3435d5de7f41
Source dataset
uspto-grants-2003_12
Patent number
US06664353B2

Reaction notes

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