tert-Butanol → Di-tert-butyl ether

HRID 432941Notes

Reaction equation

HRID 432941 reaction equation
ClC1C=C(C=C(F)C=1)N[C:6]1[C:15]2[C:10](=CC(F)=C([N+]([O-])=O)[CH:14]=2)N=CN=1.N1(CCCO)CCOCC1.[C:34]([OH:38])([CH3:37])([CH3:36])[CH3:35]>>[C:34]([O:38][C:15]([CH3:14])([CH3:6])[CH3:10])([CH3:37])([CH3:36])[CH3:35]

Participants

4

Reactant 3

HCID 6386tert-ButanolHCID 1995763-Morpholino-1-propanolHCID 18760763HCID 18760763, compound

Product 1

HCID 22541Di-tert-butyl ether

Procedure

This reaction was all the more surprising since the tert.-butyl alcohol present in the reaction mixture does not react with (V) in an analogous manner to the 3-morpholin-4-yl-propan-1 -ol (VI) to give the corresponding tert.-butyl ether.

Sources & evidence

ORD record
ord-5cbca0d023a7493b984c49edfd085e07
Source dataset
uspto-grants-2003_12
Patent number
US06664390B2

Reaction notes

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