反应详情

温度

2.5 °C

30 g (0.1 mol) of N-(2-chloro-4-fluorophenyl)-N-[(chloromethyl)sulfonyl]acetamide was dissolved in a mixture of 150 mL of concentrated sulfuric acid and 50 mL of 30% oleum with stirring. The mixture was cooled to 0-5° C. and 9.2 mL of the nitrating agent, made from equal volumes of concentrated sulfuric acid and fuming nitric acid, was added slowly keeping the temperature below 5° C. Another 50 mL of oleum and 30 g of the starting material were then added, followed by the further dropwise addition of 9.2 mL of the nitrating agent, allowing the mixture to warm up to 10° C. The mixture was stirred for an additional 40 minutes at 10-15° C. and poured with vigorous stirring onto ice. The precipitated yellow solid was filtered off, washed with water and dried to yield 63.5 g (92%) of the title compound as a solid, which was recrystallized from ethyl acetate, melting at 183-187° C.

1. additionwas added slowly
2. customthe temperature below 5° C
3. additionfollowed by the further dropwise addition of 9.2 mL of the nitrating agent
4. temperatureto warm up to 10° C
5. stirringThe mixture was stirred for an additional 40 minutes at 10-15° C.
6. additionpoured
7. stirringwith vigorous stirring onto ice
8. filtrationThe precipitated yellow solid was filtered off
9. washwashed with water
10. customdried