HCID 11679981, compound → 3-isopropyl-3H-benzotriazole-5-carboxylic acid

HRID 433015Notes

Reaction equation

HRID 433015 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[NH:11][CH:12]([CH3:14])[CH3:13].[N:15]([O-])=O.[Na+]>Cl.O>[CH:12]([N:11]1[C:3]2[CH:4]=[C:5]([C:6]([OH:8])=[O:7])[CH:9]=[CH:10][C:2]=2[N:1]=[N:15]1)([CH3:14])[CH3:13]

Participants

5

Reactant 2

HCID 11679981HCID 11679981, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 115357913-isopropyl-3H-benzotriazole-5-carboxylic acidYield 77.4%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

To a stirred, cold (0° C.) mixture of 4-amino-3-isopropylamino-benzoic acid (11 g) in 120 mL of 6 N hydrochloric acid was added drop-wise a solution of 5.9 g of sodium nitrite in 40 mL of water. After 2 hours the solids were collected by filtration, washed with water, and dried to give 9 grams of 3-isopropyl-3H-benzotriazole-5-carboxylic acid.

Workup

  1. filtrationAfter 2 hours the solids were collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-abdfaec897864829b313177504c7942e
Source dataset
uspto-grants-2003_12
Patent number
US06664395B2

Reaction notes

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