Ammonium Chloride → HCID 18760807, compound

HRID 433021Notes

Reaction equation

HRID 433021 reaction equation
C[O:2][C:3]([C:5]1[CH:15]=[CH:14][C:8]2[N:9]=[N:10][N:11]([CH2:12][CH3:13])[C:7]=2[CH:6]=1)=O.[BH4-].[Li+].[Cl-].[NH4+]>O1CCCC1.CO>[CH2:12]([N:11]1[C:7]2[CH:6]=[C:5]([CH2:3][OH:2])[CH:15]=[CH:14][C:8]=2[N:9]=[N:10]1)[CH3:13]

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 4148881Lithium borohydrideHCID 45094786HCID 45094786, compound

Product 1

HCID 18760807HCID 18760807, compoundYield 105.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

3-Ethyl-3H-benzotriazole-5-carboxylic acid methyl ester (0.143 g) was diluted with tetrahydrofuran (2 mL) and methanol (0.06 mL). Lithium borohydride (0.023 g) was added and the solution was allowed to stand at 23° C. for 30 minutes. The reaction was then poured onto saturated ammonium chloride and extracted with ethyl acetate. The organic layer was dried with sodium sulfate and concentrated to give (3-Ethyl-3H-benzotriazol-5-yl)-methanol (0.13 g).

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-fb1130f7717243aea07e13d3354aee38
Source dataset
uspto-grants-2003_12
Patent number
US06664395B2

Reaction notes

Loading…