反应详情

10% Palladium on charcoal (0.3 g), was added to a solution of compound 12 (10.0 g, 28 mmol) in ethyl acetate (300 ml). The solution was evacuated and left stirring with hydrogen at atmospheric pressure for 24 h. The catalyst was filtered off and the solvent removed in vacuo to yield a yellow oil which was purified by column chromatography (dichloromethane) on silica to yield the pure colourless oil. Yield 5.8 g (77%). [α]D=−33.7° at 25° C.

1. customThe solution was evacuated
2. waitleft
3. filtrationThe catalyst was filtered off
4. customthe solvent removed in vacuo
5. customto yield a yellow oil which
6. customwas purified by column chromatography (dichloromethane) on silica
7. customto yield the pure colourless oil
8. customat 25° C.