反应详情

A mixture of 1-(3,3-diethoxypropyl)tetrahydropyrimidin-2-one (1 g, 4.35 mmole), and 1.0 g Dowex 50W2-200 ion exchange resin in 3% aqueous tetrahydrofuran (30 mL) was heated under reflux for 24 hours. The mixture was filtered, the filtrate was concentrated and the residue dissolved in dichloromethane (30 mL), dried with magnesium sulfate, and concentrated to give 3-(2-oxo-tetrahydropyrimidin-1-yl)-propionaldehyde (0.46 g).

1. temperaturewas heated
2. temperatureunder reflux for 24 hours
3. filtrationThe mixture was filtered
4. concentrationthe filtrate was concentrated
5. dissolutionthe residue dissolved in dichloromethane (30 mL)
6. dry with materialdried with magnesium sulfate
7. concentrationconcentrated