反应详情

The crude product from step 3 was dissolved in 30 ml acetonitrile and distributed into 30 vials (2 ml size) preloaded with potassium carbonate (300 mg, 2.3 mmol). Next, 1-bromo-3-phenylporpane (135 μl, 0.135 mmol) was then added and the mixture was shaked on a robital shaker for 18 hours at room temperature. The reaction was then worked up by pipetting out most of the solution and running through a prep HPLC using the Gilson system. The product (62 mg, 54%) was obtained by stripping off the solvent on a speed-vac.

1. additionNext, 1-bromo-3-phenylporpane (135 μl, 0.135 mmol) was then added