反应详情

A mixture of [5-(3-fluoro-benzyloxy)-pyridin-2-yl]-methanol (3.8 g, 16.3 mmol), MnO2 (12 g, 138 mmol) and chloroform (50 ml) was heated under reflux for 30 min. The dark solids were then removed by filtration over celite. The filtrate was evaporated and the residue purified by chromatography (SiO2, AcOEt-hexanes 1:1) to afford the title compound (3.0 g, 80%) as a light yellow oil with solidified on standing. MS: m/e=232.2 (M+H+).

1. temperaturewas heated
2. temperatureunder reflux for 30 min
3. customThe dark solids were then removed by filtration over celite
4. customThe filtrate was evaporated
5. customthe residue purified by chromatography (SiO2, AcOEt-hexanes 1:1)