[5-(3-Fluoro-benzyloxy)-pyridin-2-yl]-methanol → 5-(3-Fluoro-benzyloxy)-pyridine-2-carbaldehyde

Participants

Reaction Steps

A mixture of [5-(3-fluoro-benzyloxy)-pyridin-2-yl]-methanol (3.8 g, 16.3 mmol), MnO2 (12 g, 138 mmol) and chloroform (50 ml) was heated under reflux for 30 min. The dark solids were then removed by filtration over celite. The filtrate was evaporated and the residue purified by chromatography (SiO2, AcOEt-hexanes 1:1) to afford the title compound (3.0 g, 80%) as a light yellow oil with solidified on standing. MS: m/e=232.2 (M+H+).

Provenance & Evidence