HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoroaniline → tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Solvent | Isopropyl Acetate | HCID 7915 | — |
| Product | tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate | HCID 23137591 | — |
Reaction Steps
Sodium triacetoxyborohydride (NaBH(OAc)3 74 g, 0.35 mol) was added to a stirred solution of 1,1-Dimethylethyl 4-oxo-1-piperidinecarboxylate (50 g, 0.25 mol) and 3-Fluoroaniline (24 ml, 0.25 mol) in isopropyl acetate (1-PrOAc, 500 ml) and the slurry stirred overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536182B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-37cc2d7a1d7c499ab3bcccd0f2ba04eb |
| Source note | uspto-grants-2013_09 |