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HRID43359

反应详情

EQUATION

反应方程式

HRID 43359 的结构方程式

REACTANTS

反应物

3
结构：Nc1cccc(F)c1
HCID9742

3-Fluoroaniline

C6H6FN

结构：CC(C)(C)OC(=O)N1CCC(=O)CC1
HCID735900

1-Boc-4-piperidone

C10H17NO3

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC(Nc2cccc(F)c2)CC1
HCID23137591

tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

C16H23FN2O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)OC(C)C
溶剂HCID7915

Isopropyl acetate

C5H10O2

PROCEDURE

实验过程

Sodium triacetoxyborohydride (NaBH(OAc)3 74 g, 0.35 mol) was added to a stirred solution of 1,1-Dimethylethyl 4-oxo-1-piperidinecarboxylate (50 g, 0.25 mol) and 3-Fluoroaniline (24 ml, 0.25 mol) in isopropyl acetate (1-PrOAc, 500 ml) and the slurry stirred overnight.