Hydrochloric Acid → HCID 69734699, compound

HRID 433669Notes

Reaction equation

HRID 433669 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH:5]([NH:25][C:26](=[O:28])[CH3:27])[CH2:6][C:7]1[O:11][N:10]=[C:9]([CH:12]([NH:17]C(OC(C)(C)C)=O)[CH2:13][CH:14]([CH3:16])[CH3:15])[CH:8]=1)[CH3:2].[ClH:30]>O1CCOCC1>[ClH:30].[CH2:1]([O:3][C:4](=[O:29])[CH:5]([NH:25][C:26](=[O:28])[CH3:27])[CH2:6][C:7]1[O:11][N:10]=[C:9]([CH:12]([NH2:17])[CH2:13][CH:14]([CH3:15])[CH3:16])[CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20610280HCID 20610280, compound

Product 1

HCID 69734699HCID 69734699, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Acetylamino-3-[3-(1-tert-butoxycarbonylamino-3-methyl-butyl)-isoxazol-5-yl]-propionic acid ethyl ester (7F) (5.95 g, 14.5 mmol) was stirred in 4N hydrochloric acid in dioxane (25 mL) at room temperature overnight. The product was concentrated and dried under high vacuum to give the title compound as a white solid (5.38 g, 100%). MS (CI) m/z 312.2 (M+1 for the free base).

Workup

  1. concentrationThe product was concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-ef82225005bb40b89ffd6fa1afe44e94
Source dataset
uspto-grants-2003_12
Patent number
US06667331B2

Reaction notes

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