反应详情

温度

80 °C

Into a mixture of 40 ml of acetic acid and 40 ml of water was added 2.2 g of an iron powder, and the mixture was heated to 80° C. Into the mixture was added 3.0 g of methyl [2-(5-acetylamino-4-fluoro-2-nitrophenoxy)phenoxy]acetate, and the mixture was heated for 30 minutes under reflux. Thereafter, the mixture was poured into water, extracted with ethyl acetate, the organic layer was washed with water, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain 2.01 g of methyl [2-(5-acetylamino-2-amino-4-fluorophenoxy)phenoxy]acetate.

1. temperaturethe mixture was heated for 30 minutes
2. temperatureunder reflux
3. extractionextracted with ethyl acetate
4. washthe organic layer was washed with water
5. washwashed with saturated aqueous sodium bicarbonate
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated