Hydrochloric Acid → HCID 69735596, compound

HRID 433816Notes

Reaction equation

HRID 433816 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[CH:17]=[C:16]([CH2:18][CH:19]([NH:25][C:26]([O:28][CH2:29][CH:30]=[CH2:31])=[O:27])[C:20]([O:22][CH2:23][CH3:24])=[O:21])[O:15][N:14]=1)=O)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[CH2:23]([O:22][C:20](=[O:21])[CH:19]([NH:25][C:26]([O:28][CH2:29][CH:30]=[CH2:31])=[O:27])[CH2:18][C:16]1[O:15][N:14]=[C:13]([CH:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)[CH:17]=1)[CH3:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20610318HCID 20610318, compound

Product 1

HCID 69735596HCID 69735596, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-[5-(2-Allyloxycarbonylamino-2-ethoxycarbonyl-ethyl)-isoxazol-3-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (3.44 g, 7.86 mmol) was dissolved in 4M hydrochloric acid in dioxane (10 mL) and stirred at room temperature for 2 hours. The reaction was then concentrated in vacuo and co-evaporated with dichloromethane to give the desired product as a brown waxy solid. MS (CI) m/z 509.9 (M+1)

Workup

  1. concentrationThe reaction was then concentrated in vacuo and co-evaporated with dichloromethane

Sources & evidence

ORD record
ord-f276985fe50e4496894c7f10f08fc660
Source dataset
uspto-grants-2003_12
Patent number
US06668527B2

Reaction notes

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