Hydrochloric Acid → HCID 69734699, compound

HRID 433824Notes

Reaction equation

HRID 433824 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH:5]([NH:25][C:26](=[O:28])[CH3:27])[CH2:6][C:7]1[O:11][N:10]=[C:9]([CH:12]([NH:17]C(OC(C)(C)C)=O)[CH2:13][CH:14]([CH3:16])[CH3:15])[CH:8]=1)[CH3:2].[ClH:30]>O1CCOCC1>[ClH:30].[CH2:1]([O:3][C:4](=[O:29])[CH:5]([NH:25][C:26](=[O:28])[CH3:27])[CH2:6][C:7]1[O:11][N:10]=[C:9]([CH:12]([NH2:17])[CH2:13][CH:14]([CH3:15])[CH3:16])[CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20610280HCID 20610280, compound

Product 1

HCID 69734699HCID 69734699, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Acetylamino-3-[3-(1-tert-butoxycarbonylamino-3-methyl-butyl)-isoxazol-5-yl]-propionic acid ethyl ester (7F) (5.95 g, 14.5 mmol) was stirred in 4N hydrochloric acid in dioxane (25 mL) at room temperature overnight. The product was concentrated and dried under high vacuum to give the title compound as a white solid (5.38 g, 100%). MS (CI) m/z 312.2 (M+1 for the free base).

Workup

  1. concentrationThe product was concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-38b0693cec484046a1945b3953e73377
Source dataset
uspto-grants-2003_12
Patent number
US06668527B2

Reaction notes

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