Hydrochloric Acid → HCID 66649504, compound

HRID 43385Notes

Reaction equation

HRID 43385 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[S:12]([N:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1)(=[O:14])=[O:13].Cl>O1CCOCC1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:9])[F:11])=[CH:4][C:3]=1[S:12]([N:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1)(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid3×HCID 666493901,1-Dimethylethyl 4-{[2-methyl-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Product 1

HCID 66649504HCID 66649504, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent4×

Procedure

1,1-dimethylethyl 4-{[2-methyl-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate (may be prepared as described in Description 29) (2.1 g, 5.14 mmol) in 1,4-dioxane (50 mL) was treated by HCl 4M in dioxane (6.43 mL, 25.7 mmol). The reaction mixture was stirred overnight at room temperature. LCMS showed a mixture of starting material and product so 8 ml of 4M HCl in dioxane were added. LCMS after 2 h showed still some starting material so 5 ml of 4M HCl in dioxane were added. LCMS after 2 h showed traces of starting material.

Workup

  1. additionwere added
  2. waitLCMS after 2 h showed still
  3. waitLCMS after 2 h showed

Sources & evidence

ORD record
ord-0fca533c07d3409cabd8340bf636fff6
Source dataset
uspto-grants-2013_09
Patent number
US08536183B2

Reaction notes

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