反应详情

1,1-dimethylethyl 4-{[2-methyl-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate (may be prepared as described in Description 29) (2.1 g, 5.14 mmol) in 1,4-dioxane (50 mL) was treated by HCl 4M in dioxane (6.43 mL, 25.7 mmol). The reaction mixture was stirred overnight at room temperature. LCMS showed a mixture of starting material and product so 8 ml of 4M HCl in dioxane were added. LCMS after 2 h showed still some starting material so 5 ml of 4M HCl in dioxane were added. LCMS after 2 h showed traces of starting material.

1. additionwere added
2. waitLCMS after 2 h showed still
3. waitLCMS after 2 h showed