反应详情

温度

0 °C

One gram of AZT was dissolved in 30 ml of anhydrous acetonitrile and added dropwise to a solution of 632 mg of malonyl chloride in 20 ml of acetonitrile at 0° C. The reaction mixture was stirred for 2 hours at 0° C. then at 8-10° C. for 4.5 hours. Thin layer chromatography was used to indicate that the reaction was complete. Water (4 ml) was added. Solvents were removed in vacuo and the residue purified by silica gel chromatography eluting with CHCl3:MeOH. Pure product was obtained in a 68% yield.

1. waitat 8-10° C. for 4.5 hours
2. customSolvents were removed in vacuo
3. customthe residue purified by silica gel chromatography
4. washeluting with CHCl3
5. customPure product was obtained in a 68% yield