Sodium Sulfite → Sodium Bromide

HRID 433890Notes

Reaction equation

HRID 433890 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:10])=[CH:4][CH:3]=1.[S:11]([O-:14])([O-:13])=[O:12].[Na+:15].[Na+]>O.C(COC)OC>[Na+:15].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:11]([O-:14])(=[O:13])=[O:12])=[CH:4][CH:3]=1.[Br-:10].[Na+:15]

Participants

6

Reactant 2

HCID 24437Sodium SulfiteHCID 5731534-Fluorophenethyl bromide

Product 2

HCID 253881Sodium BromideYield 626.8%HCID 88013906HCID 88013906, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 2-(4-fluorophenyl)ethyl bromide (1.8 g, 8.9 mmol) (Ref. Chim. Ther., 1969, 4(3),185) and sodium sulfite (2.24 g, 8.9 mmol) in water (5 ml) and dimethoxyethane (5 ml) was heated under reflux for 21 hours. The mixture was then left for 72 hours at room temperature. The mixture was concentrated under vacuum to leave the title compound as a crytalline mixture with sodium bromide (2.87 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 21 hours
  3. concentrationThe mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-c8c5135b9fdf4884bd42cedcd678eca9
Source dataset
uspto-grants-2003_12
Patent number
US06670362B2

Reaction notes

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